We identified a previously unrecognized signaling network in the striatum that can propagate robust signals over long distances in the brain. This network is responsible for information processing and generates specific blueprints for different brain stimuli. Importantly, the signals propagating through the network can be amplified or inhibited by therapeutic agents that are already available, well tolerated, and FDA approved. So far, we focused our studies on three components in this network. Our ultimate goal is to identify all components of the brain network and to find the weak links that break in the early stages of Alzheimer’s and Parkinson’s disease. Endowed with this knowledge we will be able to restore the integrity of the brain network and with it to prevent the cognitive decline, or at least to slow its progression.